I grew up with the RGB and always loved it a lot. I watched the cartoon a lot and had a decent amount of the toys.
I still have my original Firehouse HQ, Ecto-1, Highway Haunter, and a few of the ghosts and gadgets!
The only original series 1 figure I had was Ray, I lost the pack soon and our dog chew his hand and foot off. I did hold onto the figure for a long time until I eventually found a replacement 15 years later. I really liked the figure a lot! I remember looking at the poster catalogs and what’s really weird is that I remember daydreaming about having all 4 RGB figures mosc hanging on the wall, all complete with the proton packs and ghosts. I never kept toys in their package and it was the 80’s when I was a kid so this was weird lol. To this day I never bought them MOSC but it’s still a small dream I have even tho I’m pretty much a loose collector. I never had a proton pack either and I always wished I had one, that was soooo cool! One of my friends had the full Kenner gear including a jumpsuit! I barely remember watching FGB, I somehow didn’t like it that much at all when I was a kid. But then again, I didn’t like the 3rd season of Transformers either! lol
A few of my friends had FGB toys. I gotta say I really loved the Ghost Command haunted house and the Ghost Buggy, they looked really neat, but my friends where complaining how fragile they where. Still cool tho. Fragile yes. It breaks when you look at it, I collect the line now because of that nostalgia factor when I was playing with the FGB toys at my friends house and it’s a small line to collect. The toys themselves are detailed for the time and a lot of fun! I finally started to collect it when I was incredibly lucky to be able to buy the Ghost Command in brand new condition. I still haven’t applied the labels yet since I want to scan them fist and maybe just hold onto them so I can make repro labels from them to apply on my GC. I am only missing the scare scooter, and might sell the Bone Troller again for the time being because it is big. I couldn’t part with the GC tho, too many good memories and too difficult to find one 
I drifted a bit off topic, time to go back on topic!
I’m not sure if you can really compare the FGB to the RGB.
RGB has comedy elements, especially sarcasm but it is really action packed with a lot of seriousness to it. I can still watch it and enjoy it to this very day.
FGB is meant to be a slapstick or bad comedy show like the old live action series. They mess up… a lot!
I did watch some FGB episodes again, but it is difficult to sit through for me. Especially when the few minutes long transformation chamber sequence show up. It does have it’s moments though.
There are only 3 things they have in common;
The RGB are REAL Ghostbusters, who really bust ghosts, that’s no contest. They live together with just one ghost; Slimer. Since we all know that since this the RGB part of the forum, I’ll go into more details from the FGB since I know a little about the FGB and I collect the toys as well. I’m by no means an expert so I could be definably wrong on a few points.
The Filmation Ghostbusters is really something different, they live in a haunted ghost house; Ghost Command which is invested by spooks, specters and ghosts. The Ansa-Bone (talking skull phone) gives them a heads up when to move and the Skelevision tells them most of the time what’s going on in the present, past of future. They use possessed stuff like the Shock Clock and Skelescope as well. They even change clothes by stepping in a haunted Skelevator which takes them into the transformation chamber which seems to be in a ghost dimension.
Their main ride is an old haunted car, the Ghost Buggy aka G.B.
Their main adversary is Prime Evil who is technically not a true ghost, but more like a wizard android.
His pet, Bat-A-Rat is some kind of mutated flying rat. also one of the “ghosts” Scared Stiff is a robotic skeleton.
So basically they try to fight fight robots and androids that control ghosts (kinda like Ganon from The Legend of Zelda cartoon controls all the monsters and skeletons) and the GB can travel through time as well with G.B. They also have a Ghostbuster coming from the future called Futura. She time travels using the Time Hopper.
The FGB are time travelers themselves as well.
The equipment they use also involve magic. They all wear magic Ghost Packs. Tracy the Gorilla wears a magic Ghost Backpack which actually contains the portable Transformation Chamber which Jake & Eddie need to gear up in their suits.
Let’s say the RGB would fight against the FGB. All the RGB need to do is bust all the ghosts in Ghost Command and then Jake & Eddie pretty much aren’t able to transform into their suits anymore. Ghost Command is where their true strength comes from imo.
Correct me if I’m wrong! It’s been awhile since I watched some FGB.